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Co-processed excipients: a revisit of its development in the past two decades; a review

Liew, Kai Bin and Hii, Shou Hui and Helal Uddin, A.B.M. and Sarker, Zaidul Islam and Chew, Yik Ling (2022) Co-processed excipients: a revisit of its development in the past two decades; a review. Journal of Pharmaceutical Negative Results, 13 (7). pp. 96-103. ISSN 0976-9234 E-ISSN 2229-7723

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A pharmaceutical excipient is a substance acts as a carrier incorporates active pharmaceutical ingredients. Excipient selection focuses on desirable characteristics of excipients. Limitations of using excipients which affect the characteristics of the granules and tablets. Co-processed excipients are produced by integrating one excipient into the other excipient at particle level. Such combination of two or more pharmacopeial or non-pharmacopeial excipients does not involve chemical reaction and only involve physical properties changes which is not possible by simple physical mixing. The introduced multicomponent-based excipients for formulation to obtain better features and tableting properties. The objectives of this revisit to discuss the development of co-processed excipients in the past two decades. This review summarizes the advantages of co-processed excipient, the manufacturing process, compilation of co-processed excipients in the literature, limitations, evaluation methods and future development of co-processed excipient. Co-processed excipients will undoubtedly attract attention from academia and pharmaceutical industry as more newer combinations of excipients and newer ways of co-processing become available Besides, rather using numerous excipients in formulation, it allows for the development and usage of single multifunctional excipients.

Item Type: Article (Journal)
Uncontrolled Keywords: Excipients, Co-processed, Tablets
Subjects: Q Science > QD Chemistry
R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica > RS192 Materia Medica-Pharmaceutical Technology
R Medicine > RS Pharmacy and materia medica > RS403 Materia Medica-Pharmaceutical Chemistry
Kulliyyahs/Centres/Divisions/Institutes (Can select more than one option. Press CONTROL button): Kulliyyah of Pharmacy > Department of Pharmaceutical Chemistry
Kulliyyah of Pharmacy
Depositing User: Dr. A. B. M. Helal Uddin
Date Deposited: 30 Dec 2022 09:42
Last Modified: 30 Dec 2022 09:55
URI: http://irep.iium.edu.my/id/eprint/102355

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